Table 3.

Network miRNAs and potentially directly or indirectly regulated protein-coding genes. The logFC-column quantifies the expression level of the miRNA within the short-lived subgroup relative to the long-lived subgroup.

miRNA	logFC	Connected gene	GeneCards annotation summary
hsa-let-7b	1.01	PAPD7	Poly(A) RNA polymerase; oncogenic MAPK signaling; DNA repair; sister chromatin adhesion
hsa-mir-10a	2.97	PBX3	Astrocytoma association; misregulation in cancer; transcription factor activity
hsa-mir-10a	2.97	HOXB3	Transcription factor in development, host gene of hsa-mir-10a
hsa-mir-128-1	− 0.54	ARPP21	cAMP-regulated phosphoprotein; nucleic acid and calmodulin binding; enriched expression in CNS
hsa-mir-130a	− 1.88	FAM69B	Cysteine-rich type II transmembrane protein of unknown function
hsa-mir-150	− 0.81	LEF1	T cell receptor binding; Wnt signaling, cancer association; transcription factor activity
hsa-mir-196b	1.16	HOXA7	Transcription factor in development
hsa-mir-486	− 0.93	LBH	transcriptional activator in mitogen-activated protein kinase signaling pathway
hsa-mir-628	− 0.60	BEND2	participation in protein and DNA interactions during chromatin restructuring or transcription
hsa-mir-6718	2.61	LRMDA	Leucin-rich; melanocyte differentiation