Table 2.
The characteristics of the three genetic variants used for haplotype located in the 19q13 loci
| SNP | Position | Mi | Ma | OR | P value for OR | MAF | HWE_P | Gene | Location |
|---|---|---|---|---|---|---|---|---|---|
| rs7259620 | 45,407,788 | A | G | 0.834 | 3.79E-19 | 0.284 | 0.737 | APOE | near-gene-5 |
| rs403155 | 45,363,299 | T | C | 0.789 | 3.30E-15 | 0.107 | 0.475 | PVRL2 | intron |
| rs157581 | 45,395,714 | C | T | 0.911 | 2.64E-19 | 0.236 | 0.250 | TOMM40 | coding-synonymous |
| rs10406604 | 45,723,986 | A | G | 0.917 | 8.58E-05 | 0.221 | 0.094 | EXOC3L2 | intron |
| rs3212986 | 45,912,736 | A | C | 0.926 | 1.64E-04 | 0.266 | 0.976 | CD3EAP | missense |
APOE Apolipoprotein E, PVRL2 Poliovirus receptor-related 2 (nectin-2 and CD112), TOMM40 Translocase of outer mitochondrial membrane 40 homolog, EXOC3L2 Exocyst complex component 3 Like 2, CD3EAP CD3e molecule associated protein, CHR Chromosome, SNP Single nucleotide polymorphism, Mi Minor allele, Ma Major allele, OR Odds ratios (OR) for serum LDL concentration in the reference of the major allele; P value for OR adjusted for age, gender, residence area, body mass index, and energy intake, MAF Minor allele frequency, HWE_P P value for Hardy-Weinberg equilibrium