Table 3.
Adjusted means in obesity status and serum lipid profiles of participants with major-, heterozygote-, and minor-alleles of the haplotype1 according to serum LDL cholesterol concentrations
| Low-LDL2 | High-LDL3 | |||||
|---|---|---|---|---|---|---|
| Major4 (n = 10,950) |
Heterozygote (n = 10,728) |
Minor (n = 2731) |
Major (n = 1782) |
Heterozygote (n = 1680) |
Minor (n = 301) |
|
| BMI (kg/m2) | 23.8 ± 2.8b | 23.9 ± 2.9b | 23.9 ± 2.8b | 24.3 ± 2.9a | 24.4 ± 2.8a | 24.2 ± 2.6b+++ |
| WC (cm) | 80.6 ± 8.7b | 80.8 ± 8.8b | 80.7 ± 8.6b | 81.9 ± 8.3a | 81.8 ± 8.2a | 81.3 ± 7.4b+++ |
| Total cholesterol (mg/dl) | 191 ± 29b | 190 ± 29b | 186 ± 30c | 238 ± 40a | 239 ± 41a | 235 ± 48a***+++ |
| LDL (mg/dl) | 114 ± 25c | 112 ± 26d | 106 ± 26e | 159 ± 39a | 158 ± 41a | 153 ± 47b***+++ |
| HDL (mg/dl) | 52.6 ± 13 | 52.8 ± 13 | 53.3 ± 13 | 53.2 ± 12 | 53.1 ± 11 | 53.2 ± 12 |
| TG (mg/dl) | 123 ± 88a | 125 ± 87ab | 132 ± 91c | 131 ± 77bc | 136 ± 71bc | 143 ± 83c**+++ |
| Ratio of LDL/ HDL | 2.34 ± 0.70b | 2.31 ± 0.72b | 2.22 ± 0.70c | 2.65 ± 1.04a | 2.62 ± 1.02a | 2.56 ± 1.65a***+++ |
1Haplotypes of APOE, PVRL2, TOMM40, EXOC3L2, and CD3EAP in the 19q13 loci; 2 Low serum LDL cholesterol < 160 mg/dl and 3 High serum LDL cholesterol ≥160 mg/dl; 4Major, heterozygotes, and minor alleles of each SNP were scored 0, 1, and 2, respectively, and the scores of the SNPs in the haplotype were added. They were divided into 3 categories (Major, Heterozygote, and Minor haplotype groups) by 0, 1–2, and 3–4, respectively. Adjusted for age, gender, residence area, body mass index (BMI), and energy intake. Values represent adjusted means±standard deviations
Significantly different from major allele group at *P < 0.05; **P < 0.01; ***P < 0.001. Significantly different by LDL status +P < 0.05; ++P < 0.01; +++P < 0.001
a,b,c Means without a common letter differ in the same row by Bonferroni test at P < 0.05