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. 2020 Jul 29;5:135. doi: 10.1038/s41392-020-00242-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The role of SOX2 in embryonic development, pluripotency, and homeostasis. SOX2 is initially expressed in pluripotent founder cells of blastocyst, and plays the key role in the embryonic development of three cell linages of ectoderm, endoderm, and mesoderm. SOX2 expression in adult stem and progenitor cells is essential for tissue homeostasis and regeneration. Dysregulation of SOX2 contributes to tumorigenesis