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. 2020 Jul 29;10:12772. doi: 10.1038/s41598-020-69682-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Antitumor efficacy of EC2629 +/− anti-CTLA-4 on FR expressing intraperitoneal ID8-Cl15 tumors in C57BL/6 mice. ID8-Cl15 tumor cells (1 × 10⁶) were inoculated intraperitoneally into C57BL/6 mice and therapy administered on randomized animals. open circle, untreated controls; filled circle, anti-CTLA-4 antibody 0.25 mg/dose, BIW, 5 doses; filled square, EC2629, 0.1 µmol/kg, BIW × 6 doses; filled diamond, EC2629+ anti-CTLA-4 antibody. N = 5 mice/group.