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. 2020 Jul 29;10:12772. doi: 10.1038/s41598-020-69682-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Stability of EC2491 in liver microsomes. Percent intact EC2491 after incubating 1 µM in (a) buffer (filled diamond), liver microsomes (rat, open circle; dog, open square; and human, open triangle) and liver microsomes + NADPH (rat, filled circle; dog, filled square; and human, filled triangle) and (b) liver microsomes (+ NADPH) from dexamethasone treated rat (filled circle), corn-oil treated rat (open circle), rifampin treated dog (filled square) or corn-oil treated dog (open square). Points, average of 2 samples; bars, s.d.