Table 1.
EC2629 plasma pharmacokinetic parameters following intravenous administration to rats.
| Group | Dose (mg/kg) | Gender | t1/2 (h) | Tmax (h) | Cmax (ng/mL) | C0 (ng/mL) | AUClast (h · ng/mL) | AUCinf (h · ng/mL) | Vz (L/kg) | Cl (L/h/kg) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 0.05 | F | 0.627 | 0.033 | 545 | 662 | 260 | 287 | 0.157 | 0.174 |
| M | 1.02 | 0.033 | 595 | 669 | 305 | 384 | 0.191 | 0.130 | ||
| 2 | 0.10 | F | 0.525 | 0.033 | 1,330 | 1,570 | 596 | 633 | 0.120 | 0.158 |
| M | 0.706 | 0.033 | 1,390 | 1,690 | 617 | 699 | 0.146 | 0.143 | ||
| 3 | 0.25 | F | 0.530 | 0.033 | 3,230 | 3,740 | 1,640 | 1,750 | 0.109 | 0.143 |
| M | 0.770 | 0.033 | 3,580 | 4,310 | 1,670 | 1930 | 0.144 | 0.129 | ||
| 4 | 0.50 | F | 0.611 | 0.033 | 6,070 | 7,060 | 3,230 | 3,540 | 0.125 | 0.141 |
| M | 1.40 | 0.033 | 7,080 | 8,450 | 5,450 | 5,510 | 0.183 | 0.0907 |