Table 4.
Prevalence and relative risk of adverse outcomes among infants exposed (maternal ZIKV PCR positive) and unexposed to Zika Virus during pregnancy in the Jundiai Zika Cohort from March 2016 to August 2017, Jundiaí, SP, Brazil.
| Variable | ZIKV RT-PCR positive women (n = 44) | ZIKV RT-PCR negative women (n = 513) | Crude RR (95% CI) |
|---|---|---|---|
| All negative outcomes | 10 (22.7%) | 129 (24.3%) | 0.9 (0.5–1.6) |
| SGA | 4 (9.1%) | 50 (9.7%) | 0.9 (0.4–2.5) |
| LBW | 4 (9.1%) | 57 (11.1%) | 0.8 (0.3–2.1) |
| Microcephaly | 2 (4.5%) | 10 (1.9%) | 2.3 (0.5–10.3) |
| Disproportionate | 2 (4.5%) | 5 (1.0%) | 4.7 (0.9–23.3) |
| Proportionate | 0 | 5 (0.8%) | – |
| Preterm | 4 (9.1%) | 68 (13.3%) | 0.7 (0.3–1.8) |
| Fetal death | 0 | 17 (3.3%) | – |
Categories are not mutually exclusive. Microcephaly was defined as infants with head circumference z-scores < − 2 at birth. Severe microcephaly was defined as head circumference z-score of < − 3 at birth. Proportionate microcephaly was defined as infants with both head circumference and birth weight z-scores of < − 2 at birth and disproportionate microcephaly as head circumference z-score of < − 2 with birth weight z-score of > − 2. SGA = small for gestational age (birth weight < 10th percentile for sex and gestational age or < − 1.28 z-scores).
LBW low birth weight (birthweight < 2,500 g).