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. 2020 Jul 29;10:12778. doi: 10.1038/s41598-020-69675-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Assessment of glycemic parameters and insulin resistance in HFD-fed WT and Gpr84^−/− mice. (A) Average body weight (%) of mice 0–8 weeks after beginning of treatment. (B) Oral Glucose Tolerance Test (OGTT) and area under the curve of the OGTT of mice after 6 weeks of treatment. (C) Average fasting blood glucose and fasting insulin levels of the mice after 6 weeks of treatment. (D) Insulin resistance (HOMA-IR) and glucose disposition index of mice after 6 weeks of treatment. (E) Measurements of total cholesterol, triglycerides and adiponectin levels in serum of HFD mice after 0 and 4 weeks of treatment. Data are presented as mean ± SEM (n ≥ 9 per group, one-way ANOVA with Bonferroni’s multicomparison test).