Table 2.
Serum concentrations (pg/ml) (mean ± SD) of cytokines in ROP patients (study group) and subjects with congenital cataract (control group).
| Cytokines | ROP patients | Controls | P value |
|---|---|---|---|
| VEGF-A | 1976.18 ± 982.45 | 683.0 ± 452.8 | 0.002 |
| VEGF-D | 110.23 ± 99.57 | 26.1 ± 48.1 | 0.012 |
| MIP-1β | 194.64 ± 146.67 | 66.0 ± 74.3 | 0.009 |
| Eotaxin | 29.72 ± 24.13 | 10.6 ± 9.3 | 0.017 |
| IP-10 | 136.99 ± 111.45 | 37.9 ± 29.2 | 0.008 |
| RANTES | 27.50 ± 17.30 | 9.1 ± 11.8 | 0.002 |
| IL-18 | 48.97 ± 41.92 | 16.8 ± 32.5 | 0.025 |
| TNF-α | 14.30 ± 8.10 | 7.8 ± 5.6 | 0.019 |
| MCP-1 | 232.96 ± 255.37 | 560.6 ± 280.7 | < 0.001 |
| EGF | 50.31 ± 39.13 | 2.6 ± 4.2 | < 0.001 |
| SCF | 23.50 ± 15.91 | 9.3 ± 2.6 | 0.007 |
| PlGF-1 | 45.62 ± 37.48 | 11.3 ± 21.7 | 0.008 |
| β-NGF | 22.31 ± 16.00 | 10.7 ± 10.4 | 0.034 |
| HGF | 113.47 ± 113.59 | 678.0 ± 419.3 | < 0.001 |
| SDF-1α | 268.55 ± 204.30 | 221.6 ± 56.7 | 0.48 |
| GRO-α | 28.26 ± 35.30 | 7.1 ± 2.4 | 0.07 |
| BDNF | 62.75 ± 78.73 | 12.6 ± 16.1 | 0.05 |
| IFN-γ | 58.74 ± 59.31 | 19.2 ± 43.3 | 0.05 |
| IL-8 | 16.32 ± 29.74 | 14.2 ± 8.4 | 0.83 |
| IL-6 | 14.31 ± 10.50 | 24.3 ± 33.9 | 0.12 |
| MIP-1α | 17.26 ± 23.20 | 10.7 ± 3.5 | 0.39 |
| IL-1RA | 892.19 ± 1,388.95 | 585.1 ± 257.8 | 0.49 |
| FGF-2 | 16.63 ± 8.73 | 17.7 ± 6.9 | 0.71 |
| PDGF-BB | 243.53 ± 388.90 | 23.0 ± 41.3 | 0.08 |
Data are shown as mean ± SD. Mann–Whitney U test.
ROP retinopathy of prematurity, VEGF vascular endothelial growth factor, MIP macrophage inflammatory protein, IP-10 interferon-induced protein10, RANTES regulated upon activation normal T cell, IL interleukin, TNF-α tumor necrosis factor-alpha, MCP monocyte chemotactic and activatingfactor, EGF epidermal growth factor, SCF stem cell factor, PIGF-1 placental growth factor-1, NGF nerve growth factor, HGF hepatocyte growth factor, SDF1α stromal cell derived factor-1α, GROα growth-regulated oncogene α, BDNF brain-derived neurotrophic factor, IFN-γ interferon gamma, IL-1Ra interleukin-1 receptor antagonist, FGF-2 basic fibroblast growth factor, PDGF-BB platelet-derived growth factor-BB.