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. 2020 Jul 29;10:12728. doi: 10.1038/s41598-020-69026-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Positive enriched maps, each green and red circles are nodes that represent a pathway. Yellow circles related a collection with a biological function; tables show the number of pathways enriched in every collection. Links between pathways were established when 2 pathways or collections had a Jaccard index > 0.4 by the expressed genes. All the enriched pathways have an FDR < 0.05 and a p value < 0.01. (a) Enriched pathways for cluster B given the paired-comparison with other clusters. (b) Enriched pathways for cluster C, black square associate all collections with a high-end biological process.