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. 2020 Jul 21;8:643. doi: 10.3389/fbioe.2020.00643

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Copyright © 2020 El-Deeb, Abo-Eleneen, Al-Madboly, Sharaf, Othman, Ibrahim and Mubarak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The regulation of the induced COX-1&2 concentrations of the skin homogenates. AgNPs treatment decreased the elevated COX-2 concentrations from 14.38 (the infected group) to 10.16 ng/mL (the treated group) without a significant difference with the non-infected group. Also, in the serum samples (B) AgNPs treatment significantly decreased the concentration of the induced COX-2 from 11.66 (the infected group) to 4.34 ng/mL (the treated group). (C) Total protein, creatinine, albumin, and urea quantifications (D) ALT and AST concentrations, in P. aeruginosa infected rats treated with AgNPs. All measurements were done in triplicate and the average was calculated ± standard deviation (SD) using GraphPad prism8. Data are represented as the mean, standard deviation and N = 3, ***p < 0.0001, and **p < 0.0125 using two-way ANOVA. *is not significant at P < 0.0001. ***is highly significant at P < 0.0001.