Table 4.
Multivariable analysis regarding the association between variables and severe hypocalcemia
| Variables | Clinically significant severe hypocalcemia | ||
|---|---|---|---|
| Adjusted p value | AOR | CI | |
| Penetrating | <0.0001 | 1.706 | 1.383, 2.103 |
| ISS | <0.0001 | 1.029 | 1.021, 1.037 |
| PRBC prior to iCa nadir | <0.0001 | 1.343 | 1.306, 1.381 |
| FFP prior to iCa nadir | <0.0001 | 1.097 | 1.057, 1.14 |
| Plt prior to iCa nadir | 0.218 | ||
| PRBCa Plt | <0.0001 | 0.971 | 0.966, 0.977 |
| Cryo prior to iCa nadir | 0.126 | ||
| Age | 0.960 | ||
Severe hypocalcemia defined as ionized calcium less than 0.9 mmol/dL or 3.6 mg/dL within 48 h of admission. Transfused blood products were maintained as continuous variables in the regression model.
aBackward stepwise logistical regression performed with variables which were significant to p ≤ 0.2 in the univariate analysis. Significant variables were then included in the final logistical model using “enter” mode
AUROC = 0.909 (95% CI = 0.897–0.921, p < 0.0001)
ISS injury severity score, PRBC packed red blood cells, iCa ionized calcium, FFP fresh Frozen plasma, Plt platelet, Cryo cryoprecipitate