Table 2.

Comparison of laboratory results between COVID-19 deceased and surviving patients

	No. of studies	MD (95%CI)	P value	Heterogeneity		Model used
				I2	Ph
White blood cell count, × 109/L	7	3.77 (2.90, 4.64)	< 0.00001	60%	0.02	Random
Neutrophil count, × 109/L	3	4.57 (2.92, 6.23)	< 0.00001	71%	0.03	Random
Lymphocyte count, × 109/L	8	− 0.37 (− 0.47, − 0.26)	< 0.00001	80%	< 0.0001	Random
Haemoglobin, g/L	5	− 0.30 (− 2.84, 2.24)	0.82	0	0.93	Fixed
Platelets, × 109/L	6	− 39.35 (− 55.78, − 22.93)	< 0.00001	65%	0.01	Random
d-dimer, mg/L	6	2.96 (1.93, 3.98)	< 0.00001	0%	0.61	Fixed
CRP, mg/L	6	80.85 (62.53, 99.18)	< 0.00001	73%	0.002	Random
PCT, ng/mL	4	0.15 (− 0.04, 0.34)	0.12	86%	0.0008	Random
ALT, U/L	6	5.07 (0.26, 9.88)	0.04	74%	0.002	Random
AST, U/L	5	14.26 (11.70, 16.81)	< 0.00001	48%	0.11	Fixed
BUN, mmol/L	3	4.00 (3.33, 4.67)	< 0.00001	0%	0.52	Fixed
Scr, μmol/L	6	21.20 (16.79, 25.61)	< 0.00001	13%	0.33	Fixed
LDH, U/L	4	246.65 (157.43, 335.88)	< 0.00001	85%	0.0002	Random
CK, U/L	4	48.98 (3.53, 94.43)	0.03	78%	0.004	Random
Alb, g/L	4	− 4.00 (− 5.17, − 2.83)	< 0.00001	0%	0.77	Fixed
Tbil, mmol/L	4	3.92 (1.94, 5.91)	0.0001	59%	0.06	Random
IL-6, pg/mL	5	27.57 (17.45, 37.69)	< 0.00001	96%	< 0.00001	Random
PT, seconds	6	1.13 (0.67, 1.60)	< 0.00001	60%	0.03	Random
APTT, seconds	3	0.64 (− 0.17, 1.44)	0.12	22%	0.28	Fixed

COVID-19 Coronavirus disease 2019, MD mean difference, CI confidence interval, CRP C-reactive protein, PCT procalcitonin, ALT alanine transaminase, AST aspartate transaminase, BUN blood urea nitrogen, Scr serum creatinine, LDH lactate dehydrogenase, CK creatine kinase, Alb albumin, Tbil total bilirubin, IL-6 interleukin-6, PT prothrombin time, APTT activated partial thromboplastin time

P ≤ 0.05 was considered to be statistically significant