. Author manuscript; available in PMC: 2020 Jul 30.

Published in final edited form as: J Neuroimaging. 2019 Oct 30;30(1):126–133. doi: 10.1111/jon.12673

Table 4.

Quantitative neuroanatomical properties estimated using standardized and nonstandardized imaging

Image Acquisition Protocol	Cortical Thickness (mm)		Hippocampal Volume (mm³)		Brain Volume (mm³)
Image Acquisition Protocol	Mean ± Standard Deviation	Coefficient of Variation	Mean ± Standard Deviation	Coefficient of Variation	Mean ± Standard Deviation	Coefficient of Variation
Standardized 1 mm isotropic	2.5 ± .1 mm^*	.04	3890 ± 443 mm³ (left)^*	.11	9.96 ± .93 × 10⁵	.09
Standardized 1 mm isotropic			4077 ± 599 mm³ (right)^*	.14
Clinical nonstandardized	2.5 ± .3 mm^*	.12	3928 ± 665 mm³ (left)	.17	1.02 ± .12 × 10⁶	.12
Clinical nonstandardized			4093 ± 829 mm³ (right)^*	.2

Note that across-subject standard deviation estimates for cortical thickness, hippocampal volume, and brain volume were all reduced when using a multicenter standardized acquisition relative to nonstandardized clinically acquired data.

Morphometric estimates with Shapiro-Wilk test P < .05, indicating nonnormal distribution of values.