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. 2020 Jul 23;11:709. doi: 10.3389/fpsyt.2020.00709

Figure 1.

Figure 1

Experimental outline. Male offspring rats were studied in parallel throughout the experiment. Two postnatal manipulations were used. PMS (MS-180): Prolonged maternal separation (MS) consists of daily separation of offspring from their mother for 180 min PND 1‑21. EH (MS-15): Early handling daily 15-min separation of offspring from their mother on PND 1‑21. Pathophysiology (ELISA analysis, immunohistochemistry analysis, Western blot analysis). PND: postnatal day. OFT: Open-field Test on PND 42. Y-maze on PND 42‑44. Body weight gain on PND 7‑56.