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. 2020 Jul 17;5(29):18472–18483. doi: 10.1021/acsomega.0c02390

Table 1. Evaluation of the Ring-Closing Metathesis in the Batch Mode.

2.3.

entry R catalyst loading (mol %) t (h) conversion (%)a 1/17/19 or 1/18/20a yield (1 + 19 or 1 + 20) (%)b yield 17 or 18 (%)
1 H Grubbs I 10 7.0 100 100:0:0 87 <5
2 H Grubbs II 5 1.5 100 97:0:3 90 <5
3 H Hoveyda II 5 1.5 100 94:0:6 95 <5
4 Me Grubbs I 10 14.0 96 20:80:0 19 75
5 Me Grubbs II 5 1.5 100 90:0:10 96 <5
6 Me Hoveyda II 5 3.0 100 92:8:0 92 8a
a

Calculated from 1H NMR of the crude.

b

Isolated yield for the inseparable mixture.