Table 2. Evaluation of the Ring-Closing Metathesis toward Goniothalamin (1) under Flow Conditions.

entry	R	conc. (M)	catalyst	loading (mol %)	T (°C)	t (min)	conv. (%)a	1/17/19 or 1/18/20a	yield (1 + 19 or 1 + 20) (%)b
1	H	0.05	Grubbs I	10	100	16.0	23	100:0:0	NDc
2	H	0.01	Grubbs II	5	100	16.0	90	79:0:21	90
3	H	0.05	Grubbs II	5	50	16.0	100	38:44:18	55
4	H	0.05	Grubbs II	5	100	16.0	100	57:0:43	78
5	H	0.05	Grubbs II	1	100	16.0	55	83:0:17	NDc
6	H	0.05	Grubbs II	5	100	8.0	97	54:0:46	79
7	H	0.01	Hoveyda II	5	100	16.0	100	44:0:56	97
8	H	0.05	Hoveyda II	5	100	16.0	100	41:0:59	58
9	Me	0.05	Grubbs I	10	100	16.0	0
10	Me	0.01	Grubbs II	5	100	16.0	80	100:0:0	75 (1 only)
11	Me	0.01	Grubbs II	5	100	32.0	75	100:0:0	65 (1 only)
12	Me	0.05	Grubbs II	5	100	16.0	100	66:0:34	94
13	Me	0.01	Hoveyda II	5	100	16.0	100	83:0:17	91
14	Me	0.05	Hoveyda II	5	100	16.0	100	63:0:37	77

^aCalculated from ¹H NMR of the crude.

^bIsolated yield for the inseparable mixture.

^cND = not determined.