Table 1.
Multi-functional roles of lncRNAs in gastric cancer
| Mode of mechanism | LncRNA | Expression | Molecular mechanism | Reference |
|---|---|---|---|---|
| Histone Modification | UCA1 | up | Mediates the trimethylation of H3K27 in promoters of p21 and SPRY1 by binding to EZH2. | 24 |
| MNX1-AS1 | up | Promotes GC progression through EZH2/BTG2 and miR-6785-5p/BCL2 aixs | 29 | |
| SNHG3 | up | Regulats neighboring MED18 gene methylation. | 30 | |
| ARHGAP27P1 | down | Epigenetically regulates p15 and p16 | 32 | |
| GCLNC1 | up | Acts as a modular scaffold of WDR5 and KAT2A complexes | 33 | |
| GCAWKR | up | Acts as a molecular scaffold of WDR5/KAT2A complexes | 34 | |
| LINC00673 | up | Acts as a scaffold for LSD1 and EZH2 | 35 | |
| FEZF1-AS1 | up | Represses the expression of P21 via binding with LSD1 | 21 | |
| HOTAIR | up | Recruits the PRC2 complex to silence target gene via H3K27me3 modification | 71 | |
| XIST | up | Interacts with EZH2 to suppress transcription of its potential target KLF2 | 72 | |
| TUG1 | up | Associates with PRC2 | 73 | |
| AGAP2-AS1 | up | Interacts with LSD1 and EZH2 and suppresses CDKN1A (P21) and E-cadherin transcription | 74 | |
| DNA methylation | SNHG1 | up | Promotes DNMT1 expression | 36 |
| MEG3 | down | DNA methylation affects the expression of MEG3 and its targeting miR-181a-5p | 39 | |
| HOTTIP | up | Increases HoxA13 expression by down-regulating DNA methylation at the E1 site | 75 | |
| LINC00673 | up | Suppresses KLF4 expression by interacting with EZH2 and DNMT1 | 76 | |
| Linc00441 | up | Recruits DNMT1 to the RB1 promoter and suppresses RB1 expression | 77 | |
| mRNA translation | MACC1-AS1 | up | Stabilizes MACC1 mRNA | 41 |
| GMAN | up | Promotes translation of ephrin A1 messenger RNA | 44 | |
| KRT7-AS | up | Stabilizes KRT7 mRNA | 78 | |
| CeRNA | KCNQ1OT1 | down | KCNQ1OT1/miR-9/LMX1A | 50 |
| LINC00682 | down | LINC00682/miR-9/LMX1A | 51 | |
| COL1A1-014 | up | COL1A1-014/miR-1273h-5p/CXCL12 | 52 | |
| MYOSLID | up | MYOSLID/miR-29c-3p/MCL-1 | 53 | |
| CTC-497E21.4 | up | CTC‑497E21.4/miR-22/NET1 | 57 | |
| LINC00346 | up | LINC00346/miR-34a-5p/CD44, NOTCH1, AXL | 79 | |
| UCA1 | up | UCA1/miR-26a/b, miR-193a, miR-214/PDL1 | 80 | |
| LINC01133 | down | LINC01133/miR-106a-3p/APC | 81 | |
| MT1JP | down | MT1JP/miR-92a-3p/FBXW7 | 82 | |
| LINC01939 | down | LINC01939/miR-17-5p/EGR2 | 83 | |
| H19 | up | H19/miR-22-3p/Snail | 84 | |
| UCA1 | up | UCA1/miR-203/ZEB2 | 85 | |
| HNF1A-AS1 | up | HNF1A-AS1/miR-661/CDC34 | 86 | |
| UFC1 | up | UFC1/miR-498/Lin28b | 87 | |
| GCRL1 | up | GCRL1/miR-885-3p/CDK4 | 88 | |
| SMARCC2 | down | SMARCC2/miR-551b-3p/TMPRSS4 | 89 | |
| BC032469 | up | BC032469/miR-1207-5p/hTERT | 90 | |
| LncRNAs act on proteins | MIR4435-2HG | up | Binds to DSP and inhibits its expression | 60 |
| KRT19P3 | down | Enhances COPS7A protein stability in GC cells | 62 | |
| LINC00707 | up | Interacts with mRNA stabilizing protein HuR | 65 | |
| HOXC-AS3 | up | Binds to YBX1 | 69 | |
| SNHG12 | up | Increases the phosphorylation of PI3K by directly binding to it | 91 | |
| SEMA3B-AS1 | down | Interacts with MLL4 | 92 | |
| pancEts-1 | up | Directly interacts with NONO to increase its interaction with ERG | 93 | |
| GALNT5 uaRNA | up | Binds with HSP90 | 94 | |
| HOTAIR | up | Interacts with Mex3b | 95 |