Table 1.

Key transcriptional factors of CSCs

Transcription factor	Cancer type	Effects	Refs
OCT4	Pancreatic	Chemoresistance, and tumorigenesis	38-41
SOX2	Glioma, breast and others	Self-renewal, tumor growth and therapy resistance	44, 45
KLF4	Breast, glioma, and osteosarcoma	Metastasis, migration and drug resistance	50-52
MYC	Glioma, breast	Drug resistance	54, 55
NANOG	Hepatic, prostate, colorectal, and brain cancers	Tumorigenesis and therapy resistance	56, 62, 63
Wnt/TCF	Breast and glioma	Metastasis and stemness maintenance	66, 67
STAT3	Breast, liver, colon leukemia and prostate	Proliferation, stemness maintenance and immunosuppressive	69-75
NF-κB	Breast, prostate, ovarian and pancreatic cancer	Pro-inflammatory, angiogenesis and invasion	76-80