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. 2020 Jul 9;10(19):8513–8527. doi: 10.7150/thno.47243

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Peptide-auric SNH can traverse the cell membrane and GSH-triggered release cargo. (A) flow cytometry analysis of cell uptakes of 1 µM ^FITCPMI-Au SNH, ^FITCPMI,^FITCBBI-Au SNH, ^FITCBBI, ^FITCDPA-Au SNH and ^DPAPMI into HCT116 cancer cells after 6h incubations. (B) schematic diagram of stimuli-responsive release of Pep-Au SNP triggered by intracellular glutathione (GSH). (C-E) PMI release from PMI-Au SNH (C), BBI release from BBI-Au SNH (D) and DPA release from DPA-Au SNH (D) under two different conditions that are PBS at pH 7.4 including 5 µM GSH to mimic extracellular environment and PBS at pH 7.4 including 5 mM GSH to mimic intracellular environment, respectively. Peptide release were quantified by HPLC, and the dates were showed by Mean±SD.