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. 2020 Jul 9;10(19):8513–8527. doi: 10.7150/thno.47243

Figure 8.

Figure 8

The molecular mechanism of PMI-Au SNH in tumor suppression. (A) schematic diagram of tumor therapeutic of the function of PMI in restoration of p53 activity. (B and C) representative IHC staining (B) and IHC score (C) for p53 protein in tumor tissues from mice with the indicated treatments (scale bar: 50 µm). (D) TUNEL score of tumor tissues from mice with the indicated treatments. (E and F) representative IHC staining (E) and IHC score (F) for p21 protein in tumor tissues from mice with the indicated treatments (scale bar: 50 µm). (G and H) representative IHC staining (G) and IHC score (H) for ki67 protein in tumor tissues from mice with the indicated treatments (scale bar: 50 µm). p values were calculated by t-test (*, p <0.05; **, p <0.01; ***, p <0.001).