Table 2.
The odds ratios (OR), sensitivity and specificity for discrimination of CRC diagnosed in different follow-up time with different cut-off values of serum piR-54265 levels
| Diagnosed within follow-up time | piR-54265 (copy/μL) | Cases/controls | ORa (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) |
|---|---|---|---|---|---|
| 0 year | < 1800 | 47/552 | 5.60 (3.27, 9.60) | 40.51 (30.37, 51.53) | 89.90 (87.27, 92.04) |
| ≥ 1800 | 32/62 | ||||
| < 1700 | 42/529 | 5.21 (3.12, 8.69) | 46.84 (36.24, 57.73) | 85.99 (83.02, 88.52) | |
| ≥ 1700 | 37/85 | ||||
| < 1600 | 36/496 | 4.84 (2.94, 7.96) | 54.43 (43.50, 64.95) | 80.78 (77.48, 83.70) | |
| ≥ 1600 | 43/118 | ||||
| < 1500 | 32/453 | 3.97 (2.42, 6.50) | 59.49 (48.47, 69.63) | 73.94 (70.33, 77.26) | |
| ≥ 1500 | 47/161 | ||||
| < 1400 | 25/413 | 4.25 (2.55, 7.08) | 68.35 (57.45, 77.55) | 67.26 (63.45, 70.86) | |
| ≥ 1400 | 54/201 | ||||
| 1 year | < 1800 | 31/552 | 5.32 (2.79, 10.17) | 41.51 (29.26, 54.91) | 89.90 (87.27, 92.04) |
| ≥ 1800 | 22/62 | ||||
| < 1700 | 31/529 | 3.66 (1.95, 6.88) | 41.51 (29.26, 54.91) | 85.83 (82.85, 88.37) | |
| ≥ 1700 | 22/85 | ||||
| < 1600 | 30/496 | 2.71 (1.47, 5.00) | 43.40 (30.95, 56.73) | 80.78 (77.48, 83.70) | |
| ≥ 1600 | 23/118 | ||||
| < 1500 | 26/453 | 2.49 (1.37, 4.50) | 50.94 (37.88, 63.88) | 73.78 (70.16, 77.10) | |
| ≥ 1500 | 27/161 | ||||
| < 1400 | 24/413 | 2.19 (1.21, 3.94) | 54.72 (41.45, 67.34) | 67.26 (63.45, 70.86) | |
| ≥ 1400 | 29/201 | ||||
| 2 years | < 1800 | 47/552 | 4.06 (2.18, 7.54) | 28.79 (19.27, 40.64) | 89.90 (87.27, 92.04) |
| ≥ 1800 | 19/62 | ||||
| < 1700 | 45/529 | 3.32 (1.84, 6.00) | 31.82 (21.85, 43.79) | 85.99 (83.02, 88.52) | |
| ≥ 1700 | 21/85 | ||||
| < 1600 | 42/496 | 2.78 (1.59, 4.89) | 36.36 (25.81, 48.42) | 80.78 (77.48, 83.70) | |
| ≥ 1600 | 24/118 | ||||
| < 1500 | 34/453 | 3.13 (1.82, 5.38) | 48.48 (36.85, 60.29) | 73.94 (70.33, 77.26) | |
| ≥ 1500 | 32/161 | ||||
| < 1400 | 30/413 | 2.82 (1.64, 4.82) | 54.55 (42.62, 65.98) | 67.26 (63.45, 70.86) | |
| ≥ 1400 | 36/201 | ||||
| 3 years | < 1800 | 87/552 | 2.35 (1.35, 4.09) | 21.10 (14.49, 29.68) | 89.90 (87.27, 92.04) |
| ≥ 1800 | 22/62 | ||||
| < 1700 | 79/529 | 2.33 (1.42, 3.82) | 27.52 (20.01, 36.56) | 85.99 (83.02, 88.52) | |
| ≥ 1700 | 30/85 | ||||
| < 1600 | 76/496 | 1.83 (1.14, 2.92) | 30.28 (22.44, 39.45) | 80.78 (77.48, 83.70) | |
| ≥ 1600 | 33/118 | ||||
| < 1500 | 69/453 | 1.66 (1.07, 2.57) | 36.70 (28.25, 46.05) | 73.94 (70.33, 77.26) | |
| ≥ 1500 | 40/161 | ||||
| < 1400 | 61/413 | 1.63 (1.06, 2.49) | 44.04 (35.08, 53.40) | 67.26 (63.45, 70.86) | |
| ≥ 1400 | 48/201 |
a: Computed with logistic regression models, adjusted for BMI, smoking and alcohol drinking status and family history of cancer. CI, confidence interval.