Table 2.

Association between plasma microRNA levels and the endpoint in Phase I.

miRNA	Univariable		Adjusted for matching variables
	HR (95% CI)	p-value	HR (95% CI)	p-value
miR-186-5p
Continuous	0.91 (0.74-1.12)	0.38	0.91 (0.73-1.14)	0.42
> 1st tertile	1.00 (0.72-1.38)	1.00	1.02 (0.73-1.41)	0.93
> median	1.03 (0.76-1.40)	0.84	1.07 (0.77-1.48)	0.69
> 2nd tertile	0.94 (0.67-1.30)	0.69	0.96 (0.68-1.34)	0.80
miR-210-3p
Continuous	1.19 (0.90-1.57)	0.23	1.23 (0.91-1.65)	0.17
> 1st tertile	1.12 (0.80-1.55)	0.51	1.16 (0.83-1.62)	0.39
> median	1.11 (0.81-1.50)	0.52	1.13 (0.82-1.55)	0.45
> 2nd tertile	1.26 (0.92-1.74)	0.15	1.31 (0.94-1.83)	0.11
miR-632
Continuous	1.17 (0.96-1.43)	0.13	1.19 (0.96-1.46)	0.11
> 1st tertile	1.39 (1.01-1.91)	0.042	1.43 (1.04-1.98)	0.030
> median	1.48 (1.11-1.98)	0.008	1.53 (1.13-2.07)	0.005
> 2nd tertile	1.24 (0.92-1.68)	0.15	1.26 (0.93-1.73)	0.14

HR Hazard ratio; CI Confidence interval.