Table 3.

Association between plasma microRNA levels and the endpoint in Phase II.

miRNA	Univariable		Adjusted for matching variables (complete observations)		Adjusted for matching variables (with imputation by the median)		Adjusted for matching variables (with MICE)
	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
miR-186-5p
Continuous	0.90 (0.71-1.14)	0.39	0.95 (0.74-1.21)	0.66	0.89 (0.70-1.13)	0.33	0.89 (0.71-1.13)	0.34
> 1st tertile	0.91 (0.68-1.22)	0.52	0.96 (0.69-1.32)	0.79	0.88 (0.65-1.19)	0.41	0.88 (0.65-1.20)	0.42
> median	0.84 (0.64-1.12)	0.23	0.85 (0.63-1.15)	0.29	0.81 (0.61-1.07)	0.14	0.81 (0.61-1.07)	0.14
> 2nd tertile	1.02 (0.76-1.37)	0.91	1.02 (0.74-1.40)	0.90	0.97 (0.72-1.32)	0.86	0.98 (0.72-1.32)	0.88
miR-210-3p
Continuous	0.85 (0.65-1.10)	0.22	1.06 (0.79-1.42)	0.68	1.10 (0.83-1.45)	0.49	1.11 (0.84-1.46)	0.47
> 1st tertile	0.84 (0.63-1.12)	0.24	1.06 (0.76-1.47)	0.72	1.06 (0.78-1.45)	0.70	1.07 (0.78-1.46)	0.68
> median	0.74 (0.56-0.98)	0.037	0.84 (0.62-1.15)	0.27	0.87 (0.65-1.17)	0.36	0.87 (0.65-1.17)	0.36
> 2nd tertile	0.98 (0.73-1.32)	0.92	1.06 (0.77-1.47)	0.70	1.10 (0.81-1.49)	0.56	1.09 (0.81-1.48)	0.56
miR-632
Continuous	0.84 (0.67-1.06)	0.14	0.93 (0.74-1.17)	0.53	0.94 (0.75-1.18)	0.58	0.94 (0.75-1.18)	0.58
> 1st tertile	0.88 (0.66-1.17)	0.38	1.02 (0.74-1.41)	0.90	1.00 (0.74-1.36)	1.00	1.00 (0.74-1.36)	1.00
> median	0.88 (0.67-1.16)	0.37	0.93 (0.68-1.26)	0.62	0.96 (0.72-1.29)	0.81	0.96 (0.72-1.29)	0.80
> 2nd tertile	0.83 (0.61-1.12)	0.22	0.88 (0.64-1.21)	0.43	0.87 (0.64-1.19)	0.39	0.87 (0.64-1.19)	0.38

HR Hazard ratio; CI Confidence interval.