Table 2.
Previous Case Reports of COVID-19 Infection in Immunocompromised Transplant Recipients
| Author | Age/ Sex | Organ Transplanted Years/Months Ago | Immunosuppression | Immunosuppression During Hospitalization | Presenting Signs/Symptoms | CT Findings | Intubation | Treatment | Disposition | Transplant Rejection |
|---|---|---|---|---|---|---|---|---|---|---|
| Guillen [11] | 50 M | Kidney: 4 y ago | Tacrolimus, everolimus, and prednisone | Held | Fever, productive cough | Bilateral ground-glass opacities | Yes | Hydroxychloroquine, lopinavir/ritonavir, interferon beta | Extubated, recovering on medical floor | No |
| Huang [3] | 58 M | Kidney: 12 y ago | Mycophenolate mofetil and corticosteroid | Unknown | Fever, cough | Unknown | Yes | Methylprednisolone | Deceased | No |
| Gandolfini [2] | 75 M | Kidney: 10 y ago | Mycophenolate mofetil, tacrolimus, and corticosteroid | Held | Cough, myalgia, and fever | Bilateral ground-glass opacities | None | Hydroxychloroquine, lopinavir + ritonavir, or darunavir + cobicistat | Deceased | No |
| Gandolfini [2] | 52 M | Kidney: 8 mo ago | Mycophenolate mofetil, tacrolimus, and corticosteroid | Held | Cough, myalgia, and fever | Bilateral ground-glass opacities | None | Hydroxychloroquine, lopinavir + ritonavir or darunavir + cobicistat and colchicine | Still in hospital, on noninvasive ventilation | No |
| Li [12] | 51 M | Heart: 15 y ago | Mycophenolate mofetil and tacrolimus | Held | Fever, diarrhea | Bilateral ground-glass opacities | None | Moxifloxacin and ganciclovir, then human gamma globulin + methylprednisolone | Discharged | No |
| Li [12] | 43 M | Heart: 3 y ago | Mycophenolate mofetil and tacrolimus | Unknown | Fever | Unknown | None | Umifenovir + ganciclovir | Discharged | No |
| Qin [13] | 37 M | Liver: perioperative | Tacrolimus and corticosteroids | Continued: lower dose | Fever | Bilateral ground-glass opacities | None | Oseltamivir, recombinant human granulocyte colony-stimulating factor and intravenous immunoglobin | Discharged | No |
| Seminari [14] | 50 M | Kidney: 4 y ago | Mycophenolate mofetil and tacrolimus | Continued | Fever and cough | Bilateral reticular opacities | None | None | Discharged | No |
| Zhu [15] | 52 M | Kidney: 12 y ago | Mycophenolate mofetil, tacrolimus, and corticosteroid | Held | Dry cough, fever, dyspnea, and gastrointestinal symptoms | Bilateral ground-glass opacities | None | Umifenovir + moxifloxacin, then methylprednisolone, intravenous immunoglobulin, and interferon alfa | Discharged | No |
| Current study | 43 F | Kidney: 12 y ago | Tacrolimus and corticosteroids | Continued | Dry cough, fever, and shortness of breath | Bilateral ground-glass opacities | None | None | Discharged | No |
Abbreviations: COVID-19, coronavirus disease 2019; CT, computed tomography.