Table 1.
Anti-SARS-CoV-2 activity of CVC, MRV, RDV, and FPV in VeroE6/TMPRSS2 cells.
| Compound | EC50a (μM) | CC50b (μM) | SIc |
|---|---|---|---|
| CVC | 19.0 ± 0.2 | >80 | >4.2 |
| MRV | >40 | >80 | – |
| RDV | 1.1 ± 0.5 | >80 | >72 |
| FPV | >80 | >80 | – |
The data of CVC and RDV represent mean ± range for two separate experiments and mean ± standard deviation for three separate experiments, respectively.
a
50% Effective concentration, based on the inhibition of virus-induced cell destruction.
b
50% Cytotoxic concentration, based on the reduction of mock-infected cell viability.
c
Selectivity index, based on the ratio of CC50 to EC50.