Table 2.
Ten-year risks by age of developing Alzheimer's disease for women based on amyloidosis alone and in the presence of neurodegeneration and mild cognitive impairment
| Normal state 1 | Amyloidosis state 2 | Neurodegeneration state 3 | Amyloidosis and neurodegeneration state 4 | Mild cognitive impairment and amyloidosis and neurodegeneration state 5 | Mild cognitive impairment and neurodegeneration state 6 | |
|---|---|---|---|---|---|---|
| 60 years | 0·2 (0·06–0·8) | 1·3 (0·6–2·5) | 3·6 (1·1–14·2) | 7·1 (4·5–10·9) | 93·5 (91·1–95·0) | 57·2 (48·2–67·9) |
| 65 years | 0·5 (0·14–1·8) | 2·5 (1·2–4·9) | 4·3 (1·4–15·0) | 10·7 (6·8–16·2) | 91·7 (89·2–93·5) | 55·4 (46·6–65·8) |
| 70 years | 1·1 (0·34–3·5) | 4·7 (2·4–8·7) | 5·5 (2·0–16·6) | 15·5 (10·0–22·8) | 88·6 (85·8–90·6) | 52·2 (43·8–62·4) |
| 75 years | 2·2 (0·74–6·5) | 7·8 (4·1–14·0) | 7·3 (2·9–19·0) | 20·8 (13·7–29·7) | 83·8 (80·7–86·2) | 47·4 (39·6–57·0) |
| 80 years | 3·7 (1·3–9·8) | 11·1 (6·0–18·7) | 9·3 (3·9–20·9) | 24·4 (16·4–33·8) | 75·8 (72·2–78·7) | 40·0 (33·1–48·6) |
| 85 years | 4·7 (1·8–11·0) | 11·5 (6·5–18·5) | 9·7 (4·3–19·3) | 23·1 (15·8–31·2) | 63·7 (59·6–67·2) | 30·0 (24·5–37·2) |
| 90 years | 3·8 (1·5–8·2) | 8·2 (4·7–12·9) | 7·1 (3·3–13·3) | 16·8 (11·5–22·6) | 46·7 (42·7–50·2) | 19·1 (15·3–24·3) |
Data are relative risk (95% CI) or %. Reproduced from Brookmeyer and Abdalla185 by permission of Elsevier.