Placebo, 0% eGFR held as reference point (represented by diamond). Filled circles represent points where hazard ratio for all-cause mortality is significant (p<0.05) compared to the reference point. eGFR indicates estimated glomerular filtration rate, calculated using adjusted serum creatinine and CKD-EPI equation. Number of patients at each follow-up time point were 6245 at 2-weeks, and 6055 at 6-weeks. Models adjusted for age, sex, race, baseline kidney function, previous myocardial infarction, smoking, NYHA functional class, diastolic blood pressure, hematocrit, potassium, and trial.