Figure 1.

Principal component analysis [PCA] score plot performed on the mucosal transcriptome datasets demonstrating clustering of subjects within, and variation between, cohorts. Dots represents samples and are coloured according to the subject cohort. Ellipse represents 95% confidence. Results are plotted according to the PC1 and PC2 scores, with the percent variation explained by the respective axis. [a] PSC-IBD versus HC; [b] UC versus HC; [c] PSC-UC versus UC; [d] PCA plots demonstrating variation between HC, UC, and PSC-UC samples. The three groups were significantly different from each other [p = 0.01]. PSC, primary sclerosing cholangitis; IBD, inflammatory bowel disease; UC, ulcerative colitis; HC, healthy controls.