Fig 5. Adipose tissue pathology in mice on HFD without Ahr knockout (Cre^neg) or with Pdgfrα-Cre Ahr knockout (Pdgfrα-Cre^pos).

A. Shown are representative examples of Cre^neg and Pdgfrα-Cre^pos mice on HFD for eWAT, iWAT, and BAT. Scale bars are 100 micrometers. B. Quantitation of adipocyte sizes in eWAT and iWAT fat depots of Cre^neg or Pdgfrα-Cre^pos mice on HFD. Quantitation was performed using the Adiposoft program in ImageJ. The upper panels represent the mean and the error bars are standard deviation. Unpaired T-test, *p<0.05. The lower panels contain descriptive graphs to show the 25^th, 50^th, and 75^th quartiles to illustrate the large differences ins droplet sizes between the groups.