Fig 1. Impact of SFTSV infection on the fetus during pregnancy.

A. A mouse model of SFTSV infection in pregnancy. B. The first and fifth lines are the pregnant dams, which were not infected with SFTSV and the fetuses were normal. The second, third, and fourth lines represent the high dose group, the low dose group, and the low dose group treated with Mitomycin C, respectively. The left column shows infection in early-gestation (E5), the right column shows infection in late-gestation (E14), and the fetuses were dissected and photographed on E17 (12dpi and 3dpi).The red arrow indicates that the fetus had undergone resorption. The blue arrow indicates placental necrosis which appeared as black. The black arrow indicates stillbirths, which were significantly smaller than those of the mock group and shows abnormal skin color. In the bottom two panels are pups that were delivered on day 1 (15dpi). They were from the mock group and the low dose group treated in early-gestation (E5). Scale bars, 2 mm.