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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2019 Aug 6;1865(11):165527. doi: 10.1016/j.bbadis.2019.08.003

Figure 5: Hemodynamic parameters following proteasome inhibition and ETA blockade in normotensive and DOCA-Salt hypertensive rats.

Figure 5:

Figure 5:

Time course (a) systolic blood pressure, (b) diastolic blood pressure, (c) mean arterial pressure (MAP) and (d) heart rate (HR) following MG132 (proteasome inhibitor) and BQ610 (selective ETA receptor antagonist) administration to normotensive (control) and hypertensive (DOCA-Salt) animals as detailed in Materials and Methods. (e) Representative traces of blood pressure and HR in normotensive and hypertensive rats following proteasome inhibition and ETA blockade. Control ●: +aCSF; ○: +MG132; ▲: +BQ610; Δ: +MG132+BQ610; DOCA-Salt ■: +aCSF; □: +MG132; ▼: +BQ610; ∇: +MG132+BQ610. *: p<0.05, **p<0.01, ***p<0.001 vs. Control+aCSF; †: p<0.05, ††: p<0.01 vs. DOCA-Salt; ‡: p<0.05 vs. DOCA-Salt+BQ610. Number of animals per experimental group: 15-18.