Table 1. Demographic characteristics of the study population, including cohort 1 and 2 from the HM and control groups.
| High Myopia (HM) | Control Group | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HM with Myopic Maculopathy | HM without Myopic Maculopathy | p-value 1 | HM with CNV | HM without CNV | p-value 2 | No HM | p-value 3 | ||||||||||||||||
| Cohort1 | Cohort 2 | p-value | Total | Cohort 1 | Cohort 2 | p-value | Total | Cohort 1 | Cohort 2 | p-value | Total | Cohort 1 | Cohort 2 | p-value | Total | Cohort 1 | Cohort 2 | p-value | Total | ||||
| Number of Patients | 176 | 103 | 279 | 55 | 31 | 86 | 98 | 79 | 177 | 133 | 55 | 188 | 124 | 53 | 177 | ||||||||
| Age (Mean ± SD) | 66.65±12.4 | 57.6 ±14.3 | 0.08 | 63.40 (±13.85) | 57.60 ±9.1 | 53.16 ±12.4 | 0.05 | 53.97 (±13.01) | 4.1x10-5 | 67.98 ±13.0 | 60.2 ±13.3 | 0.002 | 64.23 (±14.23) | 61.89 ±11.1 | 53.15 ±11.8 | 6.2x10-4 | 58.58 (±13.71) | 9.3x10-4 | 76.60 ±14.8 | 71.15 ±13.7 | 0.120 | 73.17 (±6.82) | 2.1x10-5 |
| Female Gender (%) | 118 (67.0) | 67 (65.0) | 0.880 | 185 (66.3%) | 30 (54.4) | 17 (54.8) | 0.990 | 47 (54.70%) | 0.0547 | 68 (69.4) | 49 (62.0) | 0.33 | 117 (66.1%) | 79 (59.4) | 36 (65.4) | 0.530 | 115 (61.17%) | 0.3310 | 65 (52.4) | 32 (59.4) | 0.410 | 97 (53.6%) | 0.0329 |
| Refractive Error (Diopters ± SD) | -13.80 ±4.69 | -14.09 ±4.69 | 0.345 | -13.90 (±4.28) | -10.20 ±3.25 | -9.22 ±2.40 | 0.220 | -9.53 (±2.39) | 3.7x10-4 | -14.15 ±4.99 | -13.42 ±4.10 | 0.340 | -13.77 (±4.59) | -12.12 ±4.19 | -12.22 ±4.47 | 0.695 | -12.10 (±4.26) | 0.0004 | -1.61 ±0.94 | -1.82 ±0.90 | 0.780 | -1.77 (±0.93) | 4.1x10-7 |
| Axial Length (mm ± SD) | 30.63±2.61 | 30.3 ±2.40 | 0.855 | 30.49 (±2.454) | 27.80 ±1.99 | 27.20 ±1.89 | 0.440 | 27.38 (±1.15) | 9.7x10-4 | 30.06 ±2.51 | 30.4 ±2.62 | 0.780 | 30.25 (±2.51) | 29.70 ±2.84 | 29.20 ±2.24 | 0.690 | 29.61 (±2.70) | 0.009 | 23.65 ±0.56 | 23.20 ±0.42 | 0.560 | 23.46 (±0.49) | 1.1x10-7 |
| Tobacco Smokers (%) | 69 (39.2) | 31 (32.6) | 0.315 | 100 (35.8%) | 31 (56.3) | 10 (37.8) | 0.150 | 41 (50%) | 0.0399 | 35 (35.7) | 24 (32.0) | 0.630 | 59 (34.1%) | 64 (48.1) | 17 (36.1) | 0.190 | 81 (43.08%) | 0.0434 | 29 (23.3) | 14 (26.4) | 0.320 | 43 (23.7%) | 0.0002 |
| Hypertension (%) | 56 (31.8) | 32 (33.6) | 0.690 | 88 (31.5%) | 16 (29.1) | 4 (14.8) | 0.180 | 20 (24.3%) | 0.2203 | 33 (33.7) | 27 (36.0) | 0.870 | 60 (34.7%) | 39 (29.3) | 9 (19.1) | 0.200 | 48 (25.5%) | 0.3320 | 62 (50.0) | 23 (43.4) | 0.210 | 85 (46.97%) | 0.0001 |
| Hypercholesterolemia (%) | 57 (32.3) | 21 (22.6) | 0.11 | 78 (27.9%) | 21 (38.2) | 4 (14.8) | 0.040 | 25 (30.5%) | 0.7790 | 38 (38.8) | 17 (23.2) | 0.040 | 55 (32.2%) | 40 (30.0) | 8 (17.0) | 0.190 | 48 (25.5%) | 0.2240 | 42 (33.8) | 16 (30.1) | 0.880 | 58 (32.05%) | 0.6930 |
HM: High myopia; CNV: Choroidal neovascularization; SD: Standard deviation.
1) P-value comparing HM-No MM with HM-MM.
2) P-value comparing HM-CNV+ with HM-No CNV
3) P-value comparing HM with Control group
Significance p < 0.05