Table 3. Comparison of the genotype frequencies between the HM vs. No HM group.
| Cohort 1 | Cohort 2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNPs | Genotype | Control Genotype frec (%) Genotype cases (n) | HM Genotype frec (%) Genotype cases (n) | Genot. Uncor. p-value | Control Genotype frec (%) Genotype cases (n) | HM Genotype frec (%) Genotype cases (n) | Genot. Uncor. p-value | Control Genotype frec (%) Genotype cases (n) | HM Genotype frec (%) Genotype cases (n) | Genotype Uncorrected p-value | Genotype OR (95% CI) |
| rs11873429 | AA/AC/CC | 91.3/8.7/0 63/3/0 | 93.4/6.0/0.6 157/10/1 | 0.79 | 94.6/5.4/0 35/2/0 | 95.2/4.8/0 79/4/0 | 0.76 | 92.5/7.5/0 98/8/0 | 94/5.6/0.4 235/14/1 | C; 0.63 | 0.80 (0.3–2.1) |
| rs577948 | AA/AG/GG | 34.4/48.7/17.2 22/31/11 | 29.8/51.6/18.6 48/83/30 | 0.71 | 26.9/34.6/38.5 7/9/10 | 33.3/43.2/23.5 27/35/19 | 0.53 | 32.2/44.4/23.3 29/40/21 | 31/48.8/20.2 75/118/49 | C; 0.62 | 1.24 (0.7–2.3) |
| rs669676 | AA/AG/GG | 35.4/45.6/19 28/36/15 | 29.3/44.2/26.5 63/95/57 | 0.27 | 33.3/56.7/10 10/17/3 | 30.7/46.5/22.8 31/47/23 | 0.22 | 34.9/48.6/16.5 38/53/18 | 29.3/45.2/25.5 92/142/80 | R; 0.08 | 1.65 (0.9–3.0) |
| rs13095226 | CC/CT/TT | 83.8/16.2/0 62/12/0 | 82.3/15.8/1.9 177/34/4 | 0.24 | 93.5/6.5/0 29/2/0 | 73/23.4/3.6 81/26/4 | 0.13 | 86.7/13.3/0 91/14/0 | 79.3/18.6/2.1 256/60/7 | R; 0.07 | NA (0.0-NA) |
| rS644242 | AA/AC/CC | 87.6/12.4/0 78/11/0 | 93.5/5.6/0.9 101/6/1 | 0.37 | 90/10/0 27/3/0 | 90.1/9.9/0 100/11/0 | 0.6 | 88.2/11.8/0 105/14/0 | 91.8/7.8/0.4 201/17/1 | C; 0.64 | 0.68 (0.3–1.6) |
| rs634990 | CC/CT/TT | 30.3/46.1/23.6 27/41/21 | 29.5/49.3/21.2 64/107/46 | 0.40 | 13.3/53.3/33.3 4/16/10 | 39.6/37.8/22.5 44/42/25 | 0.017 | 26.1/47.9/26.1 31/57/31 | 33.1/45.4/21.5 108/148/70 | D; 0.43 | 0.71 (0.4–1.2) |
| rs74315511 | CC/CT/TT | 89 | 213 | - | 30 | 110 | - | 119 | 322 | - | - |
| rs8139305 | AA/AG/GG | 88 | 213 | - | 29 | 110 | - | 117 | 322 | - | - |
Chr: Chromosome; Genotype freq: Genotype frequency; OR: Odds ratio; CI: Confidence interval; P-value: value from logistic regression model; P value significance < 0.05. C; Codominant model (XX vs XY vs YY), R; Recessive model (XX-XY vs YY) D; Dominant model (XX vs XY-YY).