Table 4. Comparison of the genotype frequencies between the MM vs. No MM group.
| Cohort 1 | Cohort 2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNPs | Genotype | MM-Genotype frec (%) Genotype cases (n) | MM+ Genotype frec (%) Genotype cases (n) | Genot. Uncor. p-value | MM- Genotype frec (%) Genotype cases (n) | MM+ Genotype frec (%) Genotype cases (n) | Genot. Uncor. p-value | MM- Genotype frec (%) Genotype cases (n) | MM+ Genotype frec (%) Genotype cases (n) | Genotype Uncorrected p-value | Genotype OR (95% CI) |
| rs11873429 | AA/AC/CC | 94.9/2.6/2.6 37/1/1 | 93/7.0/0 119/9/0 | 0.08 | 100/0/0 15/0/0 | 94.1/5.9/0 64/4/0 | 0.24 | 96.3/1.8/1.8 52/1/1 | 93.4/6.6/0 183/13/0 | C; 0.076 | 3.86 (0.5–38.4) |
| rs577948 | AA/AG/GG | 42.2/36.8/21 16/14/8 | 26/56.1/17.9 32/69/22 | 0.19 | 25/55/20 5/11/4 | 36/39.3/24.7 22/24/15 | 0.38 | 36.2/43.1/20.7 21/25/12 | 29.4/50.5/20.1 54/93/37 | C; 0.49 | 1.26 (0.7–2.5) |
| rs669676 | AA/AG/GG | 27.4/31.4/41.2 14/16/21 | 29/48.8/22.2 47/79/36 | 0.006 | 21.7/60.9/17.4 5/14/4 | 33.3/42.3/24.4 26/33/19 | 0.37 | 25.7/40.5/33.8 19/30/25 | 30.4/46.7/22.9 73/112/55 | R; 0.06 | 0.54 (0.3–1.1) |
| rs13095226 | CC/CT/TT | 89.4/10.6/0 42/5/0 | 80.6/17.6/1.8 133/29/3 | 0.29 | 76.9/23.1/0 20/6/0 | 71.8/23.5/4.7 61/20/4 | 0.44 | 84.9/15.1/0 62/11/0 | 77.6/19.6/2.8 194/49/7 | R; 0.10 | NA (0.00-NA) |
| rS644242 | AA/AC/CC | 90.9/9.1/0 10/1/0 | 94.6/5.4/0 88/5/0 | 0.88 | 88.4/11.6/0 23/3/0 | 90.6/9.4/0 77/8/0 | 0.86 | 89.1/10.8/0 33/4/0 | 92.3/7.2/0.5 168/13/1 | C; 0.83 | 0.84 (0.2–3.1) |
| rs634990 | CC/CT/TT | 36.7/44.9/18.4 18/22/9 | 27.7/50.6/21.7 46/84/36 | 0.11 | 48/40/12 12/10/3 | 37.2/37.2/25.6 32/32/22 | 0.15 | 40.5/43.2/16.2 30/32/12 | 31/46/23 78/116/58 | R; 0.043 *0.270 | 2.08 (1.0–4.4) |
| rs74315511 | CC/CT/TT | 49 | 164 | - | 26 | 83 | - | 75 | 247 | - | - |
| rs8139305 | AA/AG/GG | 47 | 164 | - | 26 | 82 | - | 77 | 246 | - | - |
Chr: Chromosome; Genotype freq: Genotype frequency; OR: Odds ratio; CI: Confidence interval; P-value: value from logistic regression model adjusted by age and gender; P value significance < 0.05. C; Codominant model (XX vs XY vs YY), R; Recessive model (XX-XY vs YY) D; Dominant model (XX vs XY-YY).
* Bonferroni correction p value.