Table 1. Upregulated proteins and their KEGG pathway interpretation from whole-brain lysate.
Fold change is calculated as (KO-WT)/WT.
| Gene ID | Protein name | Fold change | KEGG Pathway |
|---|---|---|---|
| AT2B1 | ATPase, Ca++ transporting, plasma membrane 1(Atp2b1) | 4.17 | Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Adrenergic signaling in cardiomyocytes, Salivary secretion, Pancreatic secretion |
| Q3UHH0, AT2B2 | ATPase, Ca++ transporting, plasma membrane 2(Atp2b2) | 6.25 | Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Adrenergic signaling in cardiomyocytes, Salivary secretion, Pancreatic secretion |
| VATA | ATPase, H+ transporting, lysosomal V1 subunit A(Atp6v1a) | 4.36 | Oxidative phosphorylation, Metabolic pathways, Phagosome, Synaptic vesicle cycle, Collecting duct acid secretion, Rheumatoid arthritis |
| AP1B1 | adaptor protein complex AP-1, beta 1 subunit(Ap1b1) | 5 | Lysosome |
| CLH1 | clathrin, heavy polypeptide (Hc)(Cltc) | 5.83 | Lysosome, Endocytosis, Synaptic vesicle cycle, Endocrine and other factor-regulated calcium reabsorption, Huntington's disease, Bacterial invasion of epithelial cells |
| ENOA | enolase 1, alpha non-neuron(Eno1) | 4.33 | Glycolysis / Gluconeogenesis, Metabolic pathways, Biosynthesis of antibiotics, Carbon metabolism, Biosynthesis of amino acids, RNA degradation, HIF-1 signaling pathway |
| HS90B | heat shock protein 90 alpha (cytosolic), class B member 1(Hsp90ab1) | 4.1 | Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, Antigen processing and presentation, NOD-like receptor signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Pathways in cancer, Prostate cancer |
| HS90A | heat shock protein 90, alpha (cytosolic), class A member 1(Hsp90aa1) | 9.4 | Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, Antigen processing and presentation, NOD-like receptor signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Pathways in cancer, Prostate cancer |
| A8DUK4 | hemoglobin, beta adult s chain(Hbb-bs) | 4.09 | African trypanosomiasis, Malaria |
| H2B1B | histone cluster 1, H2bb(Hist1h2bb) | 4.67 | Alcoholism, Viral carcinogenesis, Systemic lupus erythematosus |
| H2B1K | histone cluster 1, H2bk(Hist1h2bk) | 4.67 | Alcoholism, Viral carcinogenesis, Systemic lupus erythematosus |
| Q8CBB6 | histone cluster 1, H2bq(Hist1h2bq) | 4.67 | Alcoholism, Viral carcinogenesis, Systemic lupus erythematosus |
| MDHM | malate dehydrogenase 2, NAD (mitochondrial)(Mdh2) | 11.75 | Citrate cycle (TCA cycle), Cysteine and methionine metabolism, Pyruvate metabolism, Glyoxylate and dicarboxylate metabolism, Metabolic pathways, Biosynthesis of antibiotics, Carbon metabolism |
| PFKAM | phosphofructokinase, muscle(Pfkm) | 4.25 | Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Fructose and mannose metabolism, Galactose metabolism, Metabolic pathways, Biosynthesis of antibiotics |
| KPYM | pyruvate kinase, muscle(Pkm) | 8.83 | Glycolysis / Gluconeogenesis, Purine metabolism, Pyruvate metabolism, Metabolic pathways, Biosynthesis of antibiotics, Carbon metabolism, Biosynthesis of amino acids |
| SNP25 | synaptosomal-associated protein 25(Snap25) | 4.33 | Synaptic vesicle cycle, Insulin secretion |
| 1433E | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide(Ywhae) | 4.17 | Cell cycle, Oocyte meiosis, PI3K-Akt signaling pathway, Hippo signaling pathway, Neurotrophin signaling pathway, Viral carcinogenesis |