Table 3. Upregulated proteins and their KEGG pathway interpretation from brain-derived endosomes.

Fold change is calculated as (KO-WT)/WT.

Gene ID	Protein name	Fold Change	KEGG PATHWAY
HMGCL	3-hydroxy-3-methylglutaryl-Coenzyme A lyase(Hmgcl)	2	Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, Butanoate metabolism, Metabolic pathways, Peroxisome
L1CAM	L1 cell adhesion molecule(L1cam)	2.5	Axon guidance, Cell adhesion molecules (CAMs)
SHLB2	SH3-domain GRB2-like endophilin B2(Sh3glb2)	2.33	Endocytosis
AP2B1	adaptor-related protein complex 2, beta 1 subunit(Ap2b1)	3.5	Endocytosis, Synaptic vesicle cycle, Endocrine and other factor-regulated calcium reabsorption, Huntington’s disease
SYAC	alanyl-tRNA synthetase(Aars)	2.17	Aminoacyl-tRNA biosynthesis
PYGB	brain glycogen phosphorylase(Pygb)	4.5	Starch and sucrose metabolism, Metabolic pathways, Insulin signaling pathway, Glucagon signaling pathway,Insulin resistance
KCC4	calcium/calmodulin-dependent protein kinase IV(Camk4)	2	Calcium signaling pathway, cAMP signaling pathway, Osteoclast differentiation, Long-term potentiation
GPX1	glutathione peroxidase 1(Gpx1)	3	Glutathione metabolism, Arachidonic acid metabolism, Thyroid hormone synthesis
PGP	phosphoglycolate phosphatase(Pgp)	3	Glyoxylate and dicarboxylate metabolism, Metabolic pathways, Biosynthesis of antibiotics, Carbon metabolism
TLN1	talin 1(Tln1)	3.33	Rap1 signaling pathway, Focal adhesion, Platelet activation, HTLV-I infection