Figure 1.

Algorithm for case definitions of immunosuppressive conditions in MarketScan claims database of Commercial and Medicare enrollees, United States, August 2012–July 2017. *These 3 conditions were deemed to be immunosuppressive. †These 3 conditions were deemed to be immunosuppressive only if enrollees were given chemotherapeutic agents or immune-modulating agents or if enrollees who had rheumatologic or inflammatory conditions were receiving systemic corticosteroids. ‡We deemed that enrollees might be given chemotherapeutic agents or immune-modulating agents and not be captured by ICD codes (from the 9th Revision, Clinical Modification, or 10th Revision, Clinical Modification) for the 6 potential immunosuppressive conditions described in the first 2 footnotes. We excluded treatment with corticosteroids for <14 days from these groups to avoid capturing enrollees who might be receiving short-term bursts of corticosteroids (e.g., those with asthma). ICD, International Classification of Diseases.