Table 5. Association between clinical and confirmed peripheral and optical neuropathy and patient characteristics among 57 patients with multidrug-resistant tuberculosis, Pitié-Salpêtrière Hospital, Paris, France, 2011–2016*.
| Characteristic | Clinical neuropathy |
Confirmed neuropathy |
|||
|---|---|---|---|---|---|
| Value | p value* | Value | p value* | ||
| Age, OR (95% CI)† | 1.83 (0.9–3.7) | 0.09 | 1.66 (0.8–3.3) | 0.14 | |
| Immunosuppression treatment, OR (95% CI) | 0.91 (0.3–2.7) | 0.98 | 2.1 (0.7–6.2) | 0.18 | |
| History of intravenous drug use, OR (95% CI) | 0.43 (0.5–4.9) | 0.43 | 1.79 (0.6–5.4) | 0.30 | |
| Opioid substitution therapy, OR (95% CI) | 1.6 (0.4–6.1) | 0.49 | 1.92 (0.5–7) | 0.32 | |
| Albumin, g/L | 0.81 (0.4–1.8) | 0.61 | 1.01 (0.5–2.2) | 0.98 | |
| Linezolid treatment duration, mo | 0.47 (0.2–1.2) | 0.10 | 1.11 (0.5–2.7) | 0.82 | |
| Culture conversion, d | 0.93 (0.8–1.1) | 0.35 | 1.15 (0.9–1.4) | 0.21 | |
| Trough linezolid concentration >2 mg/L | 2.07 (0.6–7.3) | 0.26 | 0.83 (0.3–2.7) | 0.76 | |
*p values from univariate logistic models. OR, odds ratio. †Risk based on age increase by 10-y intervals.