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. 2020 Jul 30;9:e59136. doi: 10.7554/eLife.59136

Table 1. Neurological manifestations of SARS-CoV-2 infection.

Neurological manifestations Observations Supportive neuro-diagnostic measures Treatment References
Stroke Ischaemic stroke, deep vein thrombosis MRI, ECG, EKG; blood test for coagulation factors, inflammatory markers Antiplatelet, anticoagulant, tissue plasminogen activator, intravenous thrombolysis Mao et al., 2020, Beyrouti et al., 2020, Zhou et al., 2020a, Li et al., 2020
Seizure Generalized seizures, convulsions, tonic-clonic seizures, status- epilepticus MRI, CT scan, EEG; CSF for viral presence Anti-epileptic medication Levetiracetam, Clonazepam and Valproate Mao et al., 2020; Duong et al., 2020; Sohal and Mansur, 2020; Bernard-Valnet, 2020
Encephalopathy Disorientation, confusion hallucinations, altered mental status, agitation, irritability, dissociated speech, lethargy MRI, EEG; CSF for viral presence Treatment for related problems such as seizures Mao et al., 2020; Poyiadji et al., 2020; Duong et al., 2020; Yin et al., 2020; Helms et al., 2020,
Encephalitis/meningitis Focal neurological defects, fever, headache, other neuropsychotic symptoms MRI, EEG; CRP levels for inflammation; CSF for viral presence Antivirals such as Acyclovir, Favipiravir, antibiotics such as Ceftriaxone, Vancomycin, and steroids Mao et al., 2020; Bernard-Valnet, 2020; Chaumont et al., 2020; Hayashi et al., 2020
Anosmia and ageusia Reduction or loss of taste and smell, without nasal obstruction Self diagnosis Usually no treatment Mao et al., 2020; Lechien, 2020; Hawthorn, 2018; Fotuhi et al., 2020; Galougahi et al., 2020; Spinato et al., 2020
Brain haemorrhage Intracranial blood loss, haemorrhagic rim enhancement in multiple parts of the brain MRI, CT scan; CSF for viral presence Intravenous immunoglobulin Mao et al., 2020, Poyiadji et al., 2020
Myalgia, partial paralysis and/or Guillain-Barré syndrome Facial drooping, muscle weakness, diplegia/tetraplegia or hemiplegia; GBS-progressive, ascending, symmetrical flaccid limb paralysis, along with areflexia or hyporeflexia with or without cranial nerve involvement MRI, CSF evaluation, CPK levels for muscle tissue damage, test for anti-ganglioside antibodies, nerve conduction studies for demyelinating neuropathy evaluation Intravenous immunoglobulin, physiotherapy Wang et al., 2020b; Toscano et al., 2020; Sedaghat and Karimi, 2020; Oxley et al., 2020; Zhou et al., 2020a; Zhao et al., 2020; Camdessanche et al., 2020