Figure 3. Summary of lncRNAs activity during adipogenesis.

Mesenchymal stromal cells contain stem cells that can be committed to white or brown precursor cells able to differentiate in white or brown adipocytes, respectively. A specific subpopulation of white adipocytes can transdifferentiate in brite/beige adipocytes following thermogenic stimuli. The picture shows several lncRNAs involved in adipocyte maturation and/or in brite/beige transdifferentiation. For each lncRNA is indicated the molecular mechanism of action: regulation of transcription or post-transcription or translation. The lncRNAs that can be target of antisense oligonucleotide (ASO) therapy are depicted.