Table 3. Biomarker candidates for predicting the pathological response to NAC with SC or PC.
| Biomarker | Category | SC arm | PC arm | Comparison between the treatment groups
P-value |
P-value for treatment interaction | ||||
|---|---|---|---|---|---|---|---|---|---|
| No. | Responders | No. | Responders | ||||||
| No. | % | No. | % | ||||||
| ZDHHC14 | < 0.608 | 8 | 7 | 87.5 | 7 | 1 | 14.3 | 0.0101 | 0.0002 |
| ≧0.608 | 15 | 5 | 33.3 | 16 | 12 | 75.0 | 0.0319 | ||
| TIMP1 | < 10.473 | 18 | 7 | 38.9 | 20 | 13 | 65.0 | 0.1927 | 0.0013 |
| ≧10.473 | 5 | 5 | 100 | 3 | 0 | 0.0 | 0.0179 | ||
| CLDN18.2 | < 23.564 | 11 | 8 | 72.7 | 17 | 7 | 41.2 | 0.1367 | 0.0016 |
| ≧23.564 | 12 | 4 | 33.3 | 6 | 6 | 100 | 0.0128 | ||
| EGFR | < 0.549 | 13 | 9 | 69.2 | 12 | 4 | 33.3 | 0.1152 | 0.0028 |
| ≧0.549 | 10 | 3 | 30.0 | 11 | 9 | 81.8 | 0.0299 | ||
| RRM1 | < 0.803 | 15 | 7 | 46.7 | 18 | 13 | 72.2 | 0.1686 | 0.0075 |
| ≧0.803 | 8 | 5 | 62.5 | 5 | 0 | 0.0 | 0.0754 | ||
| MUC2 | < 14.04 | 18 | 7 | 38.9 | 19 | 12 | 63.2 | 0.1939 | 0.0077 |
| ≧14.04 | 5 | 5 | 100 | 4 | 1 | 25.0 | 0.0476 | ||
| DSG2 | < 4.312 | 10 | 3 | 30.0 | 12 | 9 | 75.0 | 0.0836 | 0.0091 |
| ≧4.312 | 13 | 9 | 69.2 | 11 | 4 | 36.7 | 0.2173 | ||
Abbreviations; SC: S-1/Cisplatin, PC: Paclitaxel/Cisplatin.