Fig. 7.

Frameshift-inducing alternative splicing generates protein isoforms with diverse functionalities. Alternative splicing of penultimate exons frequently extends the upon reading frame into the supposed 3′UTR. The resulting protein variants are identical to the full-length versions except a novel C-terminus. The novel C-termini are enriched in proline and PxxP motifs (top). This can (1) destabilize the resulting protein, (2) destabilize the protein together with interaction partners, and (3+4) modify protein-protein interactions