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. 2020 Jul 30;18:94. doi: 10.1186/s12915-020-00817-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Supernumerary GFI axonal projections in dfmr1^50M null mutants. a The giant fiber interneuron (GFI) visualized with 91H05-Gal4 driving the membrane marker UAS-mcd8::gfp (green) in the w¹¹¹⁸ genetic background control (left) and the dfmr1^50M null mutant (right). In the controls, GFI axonal bends have relatively few projections compared to an excess number of overgrown projections in the mutants. Arrows indicate representative axon projections. b Iontophoretic TRITC-dextran dye injection (magenta) in w¹¹¹⁸ (left) and dfmr1^50M (right) stocks show the same projection phenotype. Scale bars, 5 μm. c Quantification of the GFP-labeled axonal projections. Each gray dot represents the average projection number of both bends in one animal. The black dot represents the average, and the red bars represent the standard error of the mean. Sample sizes: w¹¹¹⁸ (n = 8) and dfmr1^50M (n = 8) animals. d Quantification of the TRITC-labeled projections. Each gray dot represents an axon bend in one animal. Sample sizes: w¹¹¹⁸ (n = 62) and dfmr1^50M (n = 48)