FIG 3.

Age at incidence compared for triple-negative breast cancer (TNBC) and non-TNBC. (A) Forest plot for weighted mean difference in mean age at incidence between TNBC and non-TNBC for 9 studies. Studies were highly homogenous, with significant odds for younger age at incidence in patients with TNBC. The P value for comparison within each study is also shown. The red diamond and dotted line represent the random-effects pooled estimate of the weighted mean difference in age at incidence between patients with and without TNBC, while the teal diamond represents the fixed-effects model (FEM). (B) Binned age at incidence. The pooled odds ratio (OR) is computed by both FEM and random-effects model (REM) because the heterogeneity among 8 studies was found to be close to 50%. The pooled OR of the FEM is represented by a teal diamond, and the REM is represented by a red diamond. The dotted line represents the OR of the REM. OR of individual studies are represented by blue boxes. The boxes are weighted by the study weights in the REM. The P value for each study is mentioned. (*)The bins represent a cutoff of 55 years instead of 50 years. (**)Cutoff of 40 years. SD, standard deviation.