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. 2020 Jul 29;10:12767. doi: 10.1038/s41598-020-69614-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Reduction of total HBV DNA (A) but not cccDNA (B) in HBV-infected PHH by CM from TLR agonist-stimulated PBMCs. PHH were infected with HBV and cultured for 3 days followed by addition of CpG-A-CM, GS-9620[L]-CM, GS-9620[H]-CM or R848–CM (diluted 1:10) or 1,000 IU of IFN-α or IFN-λ. CM was added again 6 DPI. Cells were grown for 3 more days and the quantities of total HBV DNA and cccDNA were determined by qPCR. Data are shown as mean ± SEM with PHH from three donors (N = 3) for CpG-A-CM, GS-9620[L]-CM, and with PHH from one donor (N = 1) for GS-9620[H]-CM, R848-CM (two biological replicates) *p < 0.05, Dunn’s test, p value adjusted by Benjamini-Hochberg (BH) method.