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. 2020 Jul 29;11:3695. doi: 10.1038/s41467-020-17157-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Relationship between the number of pseudogenes and functional paralogs for a given parent gene (left—duplicated pseudogenes, right—processed pseudogenes). The number of parent genes associated with processed pseudogenes in strains is 11,571, and the number of parent genes associated with duplicated pseudogenes in strains is 3,758. The average number of pseudogenes per parent per strain was obtained by dividing the total number of pseudogenes across all strains by the total number of strains (18). Fitting lines show a vague correlation between the number of functional vs. disabled copies of a gene, with a linear fit for duplicated pseudogenes and a negative logarithmic fit for processed pseudogenes. The grey area is the ±SD (standard deviation) of the fitting line. b Distribution of reference processed pseudogenes (y-axis) in human (n = 8,081) and mouse (n = 9,979) as a function of age (x-axis). The pseudogene age is approximated as sequence similarity to the parent gene.