Table 1:
Top loci identified considering different OD and OE phenotypic definitions.
| Single-variant Associations | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Phenotype | Meta-analysis | rsid | Chromosome | Location (bp) | Effect Allele | Other Allele | Effect Allele Frequency | Z score | P value |
| ODunexposed | AFR | rs201123820 | 18 | 47025347 | T | TAAACAAAAACA | 0.019 | 5.547 | 2.90E-08 |
| OEcontrols | EUR | rs9291211 | 4 | 42139132 | A | G | 0.782 | −5.387 | 7.16E-08 |
| Trans-ancestry | rs12461856 | 19 | 55433852 | A | G | 0.8402 | −5.606 | 2.07E-08 | |
| Gene-based Associations | |||||||||
| Phenotype | Meta-analysis | Gene | Chromosome | Location-Start (bp) | Location-End (bp) | SNP (n) | Z score | P value | |
| ODunexposed | AFR | C18orf32 | 18 | 47008028 | 47013622 | 18 | 4.633 | 2E-06 | |
| OEcontrols | EUR | BEND4 | 4 | 42112955 | 42154895 | 81 | 4.756 | 1E-06 | |
| Trans-ancestry | SDCCAG8 | 1 | 243419320 | 243663394 | 407 | 4.686 | 1E-06 | ||