Table 1.

iOAT titration schedule and maintenance doses of self-administered IV or IM hydromorphone in two doses daily

	Case 1		Case 1		Case 2		Case 3
	Titration #1		Titration #2
	Dose #1	Dose #2	Dose #1	Dose #2	Dose #1	Dose #2	Dose #1	Dose #2
Titration
Day 1	20	20	45+30*	50+30*	15+30*	45+10*	15+30*	45+30*
Day 2	40	60	80+20*	100	45+30*	50+30*	50+30*	80+20*
Day 3	60	80	100	100	80	80	100	100
Day 4	80	90	-	-	-	-	-	-
Day 5	90	90	-	-	-	-	-	-
Maintenance
Hydromorphone IV	90	90	140	140	60	60	150	150
Oral OAT (SROM)	-		400		600		400

^{^}All doses in milligrams (mg). Doses are at least 3 hours apart with 20 minute post-dose observation period.

^*Top-up doses given 20 minutes later if no signs of intoxication based on clinical judgement by nurse or physician and discussion with patient.